Vascular Mimicry of Granulosa Cells: a New Concept of Corpeus Luteum Development?
Identifieur interne : 000D94 ( Main/Exploration ); précédent : 000D93; suivant : 000D95Vascular Mimicry of Granulosa Cells: a New Concept of Corpeus Luteum Development?
Auteurs : R. M. Hirschberg [Allemagne] ; J. Plendl [Allemagne]Source :
- Anatomia, Histologia, Embryologia [ 0340-2096 ] ; 2005-12.
Abstract
So far, it was generally accepted that newly formed blood vessels are exclusively comprised of endothelial cells, and complemented by pericyte and myocyte recruitment during vessel maturation. Accordingly, participation of non‐endothelial cells in the formation of blood vessels has rarely been suggested. Recently, evidence supporting the existence of tumour vessels lined by non‐endothelial cells has emerged. Consequently, the concept of the inherent capacity of non‐endothelial cells to behave like endothelial cells has been discussed for tumours, and this pathomechanism has been termed vascular mimicry. The corpus luteum is one of the most intensely vascularized tissues, and angiogenesis in the corpus luteum is more effective than in highly malignant tumours. Our results indicate active involvement of granulosa cells in luteal angiogenesis, and the aim of this study was to shed more light on this exciting prospect. The study was based on cultured granulosa cells isolated from the bovine ovary in different stages of follicle maturation. Morphology of angiogenic granulosa cells was studied by phase contrast, transmission electron and scanning electron microscopy. Expression of angiogenesis‐regulating factors and their receptors was demonstrated by polymerase chain reaction (RT‐PCR). Cultured granulosa cells underwent changes reminiscent of endothelial angiogenesis, i.e., migration, proliferation, differentiation and three‐dimensional organization, and expressed angiogenesis‐regulating factors and their receptors. Our results suggest a tight regulatory and structural association of endothelial and granulosa cells in luteal angiogenesis, suggesting physiological vascular mimicry in the ovary.
Url:
DOI: 10.1111/j.1439-0264.2005.00669_42.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001559
- to stream Istex, to step Curation: 001557
- to stream Istex, to step Checkpoint: 000704
- to stream Main, to step Merge: 000E39
- to stream Main, to step Curation: 000D94
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Vascular Mimicry of Granulosa Cells: a New Concept of Corpeus Luteum Development?</title><author><name sortKey="Hirschberg, R M" sort="Hirschberg, R M" uniqKey="Hirschberg R" first="R. M." last="Hirschberg">R. M. Hirschberg</name></author><author><name sortKey="Plendl, J" sort="Plendl, J" uniqKey="Plendl J" first="J." last="Plendl">J. Plendl</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:EA115138F99B7068BFC7E47C32DD6690DB0B61A4</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1111/j.1439-0264.2005.00669_42.x</idno><idno type="url">https://api.istex.fr/document/EA115138F99B7068BFC7E47C32DD6690DB0B61A4/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001559</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001559</idno><idno type="wicri:Area/Istex/Curation">001557</idno><idno type="wicri:Area/Istex/Checkpoint">000704</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000704</idno><idno type="wicri:doubleKey">0340-2096:2005:Hirschberg R:vascular:mimicry:of</idno><idno type="wicri:Area/Main/Merge">000E39</idno><idno type="wicri:Area/Main/Curation">000D94</idno><idno type="wicri:Area/Main/Exploration">000D94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Vascular Mimicry of Granulosa Cells: a New Concept of Corpeus Luteum Development?</title><author><name sortKey="Hirschberg, R M" sort="Hirschberg, R M" uniqKey="Hirschberg R" first="R. M." last="Hirschberg">R. M. Hirschberg</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Veterinary Anatomy, Freie Universität Berlin, Koserstr. 20, D14195 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Plendl, J" sort="Plendl, J" uniqKey="Plendl J" first="J." last="Plendl">J. Plendl</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Veterinary Anatomy, Freie Universität Berlin, Koserstr. 20, D14195 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Anatomia, Histologia, Embryologia</title><idno type="ISSN">0340-2096</idno><idno type="eISSN">1439-0264</idno><imprint><publisher>Blackwell Verlag GmbH</publisher><pubPlace>Berlin, Germany</pubPlace><date type="published" when="2005-12">2005-12</date><biblScope unit="volume">34</biblScope><biblScope unit="supplement">s1</biblScope><biblScope unit="page" from="19">19</biblScope><biblScope unit="page" to="19">19</biblScope></imprint><idno type="ISSN">0340-2096</idno></series><idno type="istex">EA115138F99B7068BFC7E47C32DD6690DB0B61A4</idno><idno type="DOI">10.1111/j.1439-0264.2005.00669_42.x</idno><idno type="ArticleID">AHE669_42_42</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0340-2096</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">So far, it was generally accepted that newly formed blood vessels are exclusively comprised of endothelial cells, and complemented by pericyte and myocyte recruitment during vessel maturation. Accordingly, participation of non‐endothelial cells in the formation of blood vessels has rarely been suggested. Recently, evidence supporting the existence of tumour vessels lined by non‐endothelial cells has emerged. Consequently, the concept of the inherent capacity of non‐endothelial cells to behave like endothelial cells has been discussed for tumours, and this pathomechanism has been termed vascular mimicry. The corpus luteum is one of the most intensely vascularized tissues, and angiogenesis in the corpus luteum is more effective than in highly malignant tumours. Our results indicate active involvement of granulosa cells in luteal angiogenesis, and the aim of this study was to shed more light on this exciting prospect. The study was based on cultured granulosa cells isolated from the bovine ovary in different stages of follicle maturation. Morphology of angiogenic granulosa cells was studied by phase contrast, transmission electron and scanning electron microscopy. Expression of angiogenesis‐regulating factors and their receptors was demonstrated by polymerase chain reaction (RT‐PCR). Cultured granulosa cells underwent changes reminiscent of endothelial angiogenesis, i.e., migration, proliferation, differentiation and three‐dimensional organization, and expressed angiogenesis‐regulating factors and their receptors. Our results suggest a tight regulatory and structural association of endothelial and granulosa cells in luteal angiogenesis, suggesting physiological vascular mimicry in the ovary.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Berlin</li></region><settlement><li>Berlin</li></settlement></list><tree><country name="Allemagne"><region name="Berlin"><name sortKey="Hirschberg, R M" sort="Hirschberg, R M" uniqKey="Hirschberg R" first="R. M." last="Hirschberg">R. M. Hirschberg</name></region><name sortKey="Plendl, J" sort="Plendl, J" uniqKey="Plendl J" first="J." last="Plendl">J. Plendl</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Eau/explor/EsturgeonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D94 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000D94 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Eau
|area= EsturgeonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:EA115138F99B7068BFC7E47C32DD6690DB0B61A4
|texte= Vascular Mimicry of Granulosa Cells: a New Concept of Corpeus Luteum Development?
}}
| This area was generated with Dilib version V0.6.27. |  |